Wednesday, 25 April, 2018

New Research says Male contraceptive Pill to be safe

Men could be taking birth control pills soon after scientists said a study found an experimental oral contraceptive shows promise. File Male pill could be on horizon as trials yield positive results
Marty Perkins | 20 March, 2018, 04:48

The tests revealed that the pill does not result in significantly negative side effects, but more research may be needed to further establish it as safe and effective.

"Longer term studies are now under way to confirm that DMAU taken every day blocks sperm production", a coauthor said in a statement.

Page says a second study of DMAU will involve 100 men, 50 in Washington and 50 in California.

The idea of contraceptive pills for men has been floating about for some time now.

While some subjects on all doses had mild weight gain, DMAU appeared safe.




Different doses of the pill were given to 83 men over the course of 28 days. Maybe the study that begins in April will present us encouraging findings as well as the one presented at ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago, on Sunday. "Dimethandrolone is different than testosterone in that it binds to both the progesterone receptor and the androgen receptor so we don't need two different steroids in order to have an effective male contraceptive", Paige added.

Previous attempts at developing an oral pill for men led to liver inflammation and toxicity, but according to Dr. Page that doesn't seem to be the case here. Similarly, Sheffield University professor of andrology Allan Pacey remarked that a "large randomized controlled trial" would be necessary to better test the male contraceptive's safety and efficacy, though he also acknowledged that the results "provide some hope" in the search for an effective oral contraceptive for men. It's 99 per cent effective when taken perfectly, Planned Parenthood wrote, but added that it's hard to do this.

The drug, yet to be named will block sperms from leaving the penis during ejaculation, researchers at Monash Institute of Pharmaceutical Sciences have said.

The testosterone levels seen in the study's participants are comparable to those seen in men who have undergone castration, or removal of the testes, Courgi said. One of the major downsides of this medical innovation - and something which had been an issue before 1960 as well - is that women are often expected to deal with birth control by themselves. She explained that many men would opt for a once daily pill that provides them with reversible contraception rather than go in for topical gels or long acting injections of DMAU that would provide longer term contraception. While women are more likely to trust their partners with contraception than you might think, quite a few men still (archaically, absurdly) believe that contraception is a woman's job.

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